Note Bibliografiche

Nota bibliografica in breve:

  • Galimberti D et al. La medicina dell?aging e dell?antiaging. Edra Edizioni 2016;
  • Galimberti D et al. Nutrigenomica e Epigenetica. Dalla biologia alla clinica. Edra Edizioni 2017;
  • Cardile V et al. Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for
  • the weight management. Nat Prod Res. 2015;29(23):2256-??60.
  • TittaL et al. Blood orange juice inhibits fat accumulation in mice. Int J Obes (Lond). 2010 Mar;34(3):578-??88. doi:
  • 10.1038/ijo.2009.266. Epub 2009 Dec 22.
  • Tsuda et al. Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Biochem Pharmacol. 2006 Apr 14;71(8):1184-??97.
  • Grosso G et al. Red orange: experimental models and epidemiological evidence of its benefits on human health. Oxid Med Cell Longev. 2013;2013:157240.
  • Dallas C et al. Clinical study to assess the efficacy and safety of acitrus polyphenolic extract of red orange, grapefruit, and orange on weight management and metabolic parameters in healthy overweight individuals. Phytother Res. 2014 Feb;28(2):212-??8.
  • Cases J et al. A 12-??week randomized double-??blind parallel pilot trial of Sinetrol XPur onbody weight, abdominal fat, waist circumference, and muscle metabolism in overweight men. Int J Food Sci Nutr. 2015;66(4):471-??7.
  • Flanagan J et al. Lipolytic activity of Svetol?, a decaffeinated green coffee bean extract. Phytother Res. 2014 Jun;28(6):946-??8.
  • Taijk N et al. The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr. 2017 Oct;56(7):2215-??2244.
  • Kumar R et al. Therapeutic promises of Chlorogenic acid with special emphasis on its anti-??obesity property. Curr Mol Pharmacol. 2019 Jul 16.
  • Gorji Z et al. The effect of green-??coffee extract supplementation on obesity: A systematic review anddose-??response meta-??analysis of randomized controlled trials. Phytomedicine. 2019 Oct;63:153018.
  • Tremblay A et al. Capsaicinoids: a spicy solution to the management of obesity?Int J Obes (Lond). 2016 Aug;40(8):1198-?? 204.
  • Whiting S et al. Saicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012 Oct;59(2):341-??8.
  • Baskaran P et al. Binding Efficacy and Thermogenic Efficiency of Pungent and Nonpungent Analogs of Capsaicin.Molecules. 2018 Dec 4;23(12). pii: E3198.
  • Josse AR et al. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise.Nutr Metab (Lond). 2010 Aug 3;7:65.
  • Snitker S et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009 Jan;89(1):45-??50.
  • Wang M et al. Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus. Sci Rep. 2016 May 5;6:25399.
  • Verpeut JL et al. Citrus aurantium and Rhodiola rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-??induced obesity. Nutr Res. 2013 Jun;33(6):503-??12.
  • Cropley M et al. The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.
  • Phytother Res. 2015 Dec;29(12):1934-??9.

Nota bibliografica in breve:

  • Galimberti D et al. La medicina dell?aging e dell?antiaging. Edra Edizioni 2016;
  • Galimberti D et al. Nutrigenomica e Epigenetica. Dalla biologia alla clinica. Edra Edizioni 2017;
  • Lau FC et al. Nutrigenomic analysis of diet-??gene interactions on functional supplements for weight management. Curr Genomics. 2008 Jun;9(4):239-??51.
  • El-??Moustafa et al. Nopal cactus (Opuntia ficus-??indica) as a source of bioactive compounds for nutrition, health and disease. Molecules. 2014 Sep 17;19(9):14879-??901.
  • Galati EM et al. Opuntia ficus indica (L.) Mill. mucilages show cytoprotective effect on gastric mucosa in rat. Phytother Res. 2007 Apr;21(4):344-??6.
  • Lopez-??Romero P et al. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet. 2014 Nov;114(11):1811-??8.
  • Nunez-??Lopez MA et al. Functional and hypoglycemic properties of nopal cladodes (O. ficus-??indica) at different maturity stages using in vitro and in vivo tests. J Agric Food Chem. 2013 Nov 20;61(46):10981-??6.
  • Aragona M et al. Opuntia ficus-??indica (L.) as a source of bioactivity compounds for health and nutrition. Nat Prod Res. 2018 Sep;32(17):2037-??2049.
  • Fassina P et al. THE EFFECT OF GARCINIA CAMBOGIA AS COADJUVANT IN THE WEIGHT LOSS PROCESS. Nutr Hosp. 2015 Dec 1;32(6):2400-??8.
  • Preuss HG et al. An overview of the safety and efficacy of a novel, natural(-??)-??hydroxycitric acid extract (HCA-??SX) for weight management. J Med. 2004;35(1-??6):33-??48.
  • Preuss HG et al. Effects of a natural extract of (-??)-??hydroxycitric acid (HCA-??SX) and a combination of HCA-??SX plus niacin-?? bound chromium and Gymnema sylvestre extract onweight loss. Diabetes Obes Metab. 2004 May;6(3):171-??80.
  • Chuah LO et al. Updates on Antiobesity Effect of Garcinia Origin (-??)-??HCA. Evid Based Complement Alternat Med. 2013;2013:751658.
  • Rondanelli M et al. Relationship between the absorption of 5-??hydroxytryptophan from an integrated diet, by means of Griffonia simplicifolia extract, and the effect on satiety in overweight females after oral spray administration. Eat Weight Disord. 2012 Mar;17(1):e22-??8.
  • Bobillo C et al. Short-??term effects of a green coffee extract-??, Garcinia c ambogia-?? and L-??carnitine-??containing chewing gum on snack intake and appetite regulation. Eur J Nutr. 2018 Mar;57(2):607-??615.
  • Ioannou S et al. Preliminary fMRI findings concerning the influence of 5-??HTP on food selection. Brain Behav. 2016 Oct 28;7(1):e00594.
  • Halford JC et al. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-??55.
  • Stohs SK. Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p-?? Synephrine. Phytother Res. 2017 Oct;31(10):1463-??1474.
  • Guo LX et al. p-??Synephrine exhibits anti-??adipogenic activity by activating the Akt/GSK3? signaling pathway in 3T3-??L1 adipocytes. J Food Biochem. 2019 Nov;43(11):e13033.
  • Haaz S et al. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev. 2006 Feb;7(1):79-??88.
  • Preuss HG et al. Citrus aurantium as a thermogenic, weight-??reduction replacement for ephedra: an overview. J Med. 2002;33(1-??4):247-??64.
  • Vladeva SV et al. Effect of chromium on the insulin resistance in patients with type II diabetes mellitus. Folia Med (Plovdiv). 2005;47(3-??4):59-??62.
  • Albarracin CA et al. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev. 2008 Jan-??Feb;24(1):41-??51.
  • Cicero AFG et al. Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-??Blind, Placebo-??Controlled, Randomized Clinical Trial on a Combined Product. High Blood Press Cardiovasc Prev. 2017 Sep;24(3):283-??288.
  • Abdollahi S et al. Zinc Supplementation and Body Weight: A Systematic Review and Dose-??Response Meta-??analysis of
  • Randomized Controlled Trials. Adv Nutr. 2019 Aug 22. pii: nmz084.
  • Lin CC et al. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):588-??92.
  • De Carvalho GB et al. Zinc’s role in the glycemic control of patients with type 2 diabetes: a systematic review. Biometals. 2017 Apr;30(2):151-??162.

Nota bibliografica in breve:

  • Galimberti D et al. La medicina dell?aging e dell?antiaging. Edra Edizioni 2016;
  • Galimberti D et al. Nutrigenomica e Epigenetica. Dalla biologia alla clinica. Edra Edizioni 2017;
  • Parafati M et al. Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-??Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-??Inflammatory Activity. Nutrients. 2018 Nov 1;10(11). pii: E1604.
  • Mannucci C et al. Clinical Pharmacology of Citrus bergamia: A Systematic Review. Phytother Res. 2017 Jan;31(1):27-??39.
  • Navarra M et al. Citrus bergamia essential oil: from basic research to clinical application. Front Pharmacol. 2015 Mar 2;6:36.
  • Mollace V et al. Hypoglycemic and Hypolipemic effects of a new lecithin formulation of Bergamot Polyphenolic Fraction:
  • a double blind, randomized, placebo-??controlled study. Endocr Metab Immune Disord Drug Targets.2018 Dec 3.
  • Giglio RV et al. The effect of bergamot on dyslipidemia. Phytomedicine. 2016 Oct 15;23(11):1175-??81.
  • Cappello AR et al. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini Rev Med Chem. 2016;16(8):619-??29.
  • Ferlazzo N et al. Anti-??Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules. 2016 Sep
  • 23;21(10). pii: E1273.
  • Liju VB et al. Gastroprotective activity of essential oils from turmeric and ginger.J Basic Clin Physiol Pharmacol. 2014 Apr 21.
  • Haniadka R et al. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 2013 Jun;4(6):845-??55.
  • Shimoda H et al. Anti-??inflammatory properties of red ginger (Zingiber officinale var. Rubra) extract and suppression of nitric oxide production by its constituents. J Med Food. 2010 Feb;13(1):156-??62. van Breemen RB et al. Cyclooxygenase-??2 inhibitors in ginger (Zingiber officinale). Fitoterapia. 2011 Jan;82(1):38-??43.
  • Grzanna R et al. Ginger-??-??an herbal medicinal product with broad anti-??inflammatory actions. J Med Food. 2005 Summer;8(2):125-??32.
  • Neyrinck AM et al. Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota. Mol Nutr Food Res. 2017 Jan;61(1).
  • Yang M et al. Rheum palmatum L. Attenuates High Fat Diet-??Induced Hepatosteatosis by Activating AMP-??Activated Protein Kinase. Am J Chin Med. 2016;44(3):551-??64.
  • Bhat AH et al. Modulation of Oxidative Stress and Hyperglycemia byRheum spiciformis in Alloxan Induced Diabetic Rats and Characterization of Isolated Compound. Drug Res (Stuttg). 2019 Apr;69(4):218-??226.
  • Appiah S et al. Antiinflammatory and Hepatoprotective Medicinal Herbs as Potential Substitutes for Bear Bile. Int Rev Neurobiol. 2017;135:149-??180.
  • Pan Tl et al. Herbal formula, Scutellariae radix and Rhei rhizoma attenuate dimethylnitrosamine-??induced liver fibrosis in a rat model. Sci Rep. 2015 Jul 2;5:11734.
  • Li P et al. Pharmacokinetics and pharmacodynamics of rhubarb anthraquinones extract in normal and disease rats.Biomed Pharmacother. 2017 Jul;91:425-??435.
  • Samu Z et al. Structure elucidation and antioxidant activity of (-??)-??isosilandrin isolated from Silybum marianum L. Chem Biodivers. 2004 Nov;1(11):1668-??77.
  • Dvorak Z et al. Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. Toxicol Lett. 2003 Feb 3;137(3):201-??12.
  • Beckmann-??Knopp S et al. Inhibitory effects of silibinin on cytochrome P-??450 enzymes in human liver microsomes. Pharmacol Toxicol. 2000 Jun;86(6):250-??6.
  • Vargas-??Mendoza N et al. Hepatoprotective effect of silymarin. World J Hepatol. 2014 Mar 27;6(3):144-??9.
  • Shaker E et al. Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage. Food Chem Toxicol. 2010 Mar;48(3):803-??6.
  • Loguercio C et al. Silybin and the liver: from basic research to clinical practice. World J Gastroenterol. 2011 May 14;17(18):2288-??301.
  • Polyak SJ et al. Identification of hepatoprotective flavonolignans from silymarin. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5995-??9.
  • Dehmlow C et al. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci. 1996;58(18):1591-??600.
  • Ali J. Marian et al, Antifibrotic Effects of Antioxidant N-??Acetylcysteine in a Mouse Model of Human Hypertrophic Cardiomyopathy Mutation, J Am Coll Cardiol., 21;47(4), febbraio 2006, pp. 827?834.
  • Tyagi SC et al. Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-??induced MMP-??1 and MMP-??9 expression, in J Cell Biochem., 61(1), 1996 Apr, pp. 139-??51.
  • Wenk J et al. Overexpression of Phospholipid-??hydroperoxide Glutathione Peroxidase in Human Dermal Fibroblasts
  • Abrogates UVA Irradiation-??induced Expression of Interstitial Collagenase/Matrix Metalloproteinase-??1 by Suppression of Phosphatidylcholine Hydroperoxide mediated NF-???B Activation and Interleukin-??6 Release* JOURNAL OF BIOLOGICAL CHEMISTRY 2004 279;(44)45634?42.
  • Abrigo J et al. N-??Acetyl Cysteine attenuates the sarcopenia and muscle apoptosis induced by chronicliver disease. Curr Mol Med. 2019 Sep 17.
  • Oliveira CP et al. N-??ACETYLCYSTEINE AND/OR URSODEOXYCHOLIC ACID ASSOCIATED WITH METFORMIN IN NON-?? ALCOHOLIC STEATOHEPATITIS: AN OPEN-??LABEL MULTICENTER RANDOMIZED CONTROLLED TRIAL. Arq Gastroenterol. 2019 Aug 13;56(2):184-??190.
  • Heil J et al. N-??acetylcysteine protects hepatocytes from hypoxia-??related cell injury. Clin Exp Hepatol. 2018 Dec;4(4):260-?? 266.
  • Hou Y et al. N-??acetylcysteine and intestinal health: a focus on its mechanism ofaction. Front Biosci (Landmark Ed). 2015 Jan 1;20:872-??91.
  • Rushworth GH et al. Existing and potential therapeutic uses for N-??acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014 Feb;141(2):150-??9.
  • Elbini Dhouib I et al. A minireview on N-??acetylcysteine: An old drug with new approaches. Life Sci. 2016 Apr 15;151:359-?? 363.
  • Gibson KR et al. Evaluation of the antioxidant properties of N-??acetylcysteine in human platelets: prerequisite for bioconversion to glutathione for antioxidant and antiplatelet activity.J Cardiovasc Pharmacol. 2009 Oct;54(4):319-??26.
  • Lasram MM et al. A review on the possible molecular mechanism of action of N-??acetylcysteine against insulin resistance and type-??2 diabetes development. Clin Biochem. 2015 Nov;48(16-??17):1200-??8.

Nota bibliografica in breve

  • Galimberti D et al. La medicina dell?aging e dell?antiaging. Edra Edizioni 2016;
  • Galimberti D et al. Nutrigenomica e Epigenetica. Dalla biologia allaclinica. Edra Edizioni 2017;
  • Carillon J et al. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action. Pharm Res. 2013 Nov;30(11):2718-?? 28.
  • Carillon J et al. Endogenous antioxidant defense induction by melon superoxide dismutase reduces cardiac hypertrophy in spontaneously hypertensive rats. Int J Food Sci Nutr. 2014 Aug;65(5):602-??9.
  • Carillon J et al. Curative diet supplementation with a melon superoxide dismutase reduces adipose tissue in obese hamsters by improving insulin sensitivity. Mol Nutr Food Res. 2014 Apr;58(4):842-??50.
  • Carillon J et al. Cafeteria diet induces obesity and insulin resistance associated with oxidative stress but not with inflammation: improvement by dietary supplementation with a melon superoxide dismutase. Free Radic Biol Med. 2013 Dec;65:254-??261.
  • Nakajima S et al. Oral supplementation with melon superoxide dismutase extract promotes antioxidant defences in the brain and prevents stress-??induced impairment of spatial memory. Behav Brain Res. 2009 Jun 8;200(1):15-??21.
  • Carillon J et al. Short-??term assessment of toxicological aspects, oxidative and inflammatory response to dietarymelon superoxide dismutase in rats. Food Chem Toxicol. 2013 May;55:323-??8.
  • Spanier G et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol. 2009 Oct;60 Suppl 4:111-??6.
  • Shakibaei M et al. Resveratrol addiction: to die or not to die. Mol Nutr Food Res. 2009 Jan;53(1):115-??28.
  • Signorelli P et al. Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J Nutr Biochem.
  • 2005 Aug;16(8):449-??66.
  • Borra MT et al. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005 Apr 29;280(17):17187-??95.
  • Ramis MR et al. Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-?? diseases. Mech Ageing Dev. 2015 Mar 27;146-??148C:28-??41.
  • Park D et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Sci Rep. 2016 Feb 23;6:21772.
  • Novelle MG et al. Resveratrol supplementation: Where are we now and where should we go? Ageing Res Rev. 2015 May;21:1-??15.
  • Sergides C et al. Bioavailability and safety study of resveratrol 500 mg tablets in healthy male andfemale volunteers. Exp Ther Med. 2016 Jan;11(1):164-??170. Epub 2015 Nov 25.
  • Karkovic Markovic A et al. Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules. 2019 May 24;24(10).
  • Parkinson L et al. The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds. Molecules. 2016 Dec 16;21(12). pii: E1734.
  • Garcia-??Moreno JC et al. Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson’s disease. Neurobiol Aging. 2019 Oct;82:60-??68.
  • Fabiani R. Anti-??cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies.Food Funct. 2016 Oct 12;7(10):4145-??4159.
  • Avilla JG et al. Mode of action of Buddleja cordata verbascoside against Staphylococcus aureus. Journal of Ethnopharmacology, Volume 66, Issue 1, July 1999, Pages 75-??78,
  • Santoro A et al. Verminoside-?? and verbascoside-??induced genotoxicity on human lymphocytes: Involvement of PARP-??1 and p53 proteins. Toxicology Letters, Volume 178, Issue 2, 5 May 2008, Pages 71-??76.
  • Serreli G et al. Biological Relevance of Extra Virgin Olive Oil Polyphenols Metabolites. Antioxidants (Basel). 2018 Nov 22;7(12).
  • Sevfi D et al. Verbascoside Attenuates Rac-??1 and HIF-??1? Signaling Cascade in Colorectal Cancer Cells. Anticancer Agents Med Chem. 2018;18(15):2149-??2155.
  • Davinelli S, Scapagnini G et al. Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review. Nutrients. 2018 Apr 22;10(4).
  • Visioli F et al. Astaxanthin in cardiovascular health and disease: mechanisms of action, therapeutic merits, and knowledge gaps. Food Funct. 2017 Jan 25;8(1):39-??63.
  • Kim SH et al. Astaxanthin Modulation of Signaling Pathways ThatRegulate Autophagy. Mar Drugs. 2019 Sep 23;17(10).
  • Fakhiri S et al. Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacol Res. 2018 Oct;136:1-??20.
  • Sztretve M et al. Astaxanthin: A Potential Mitochondrial-??Targeted Antioxidant Treatment in Diseases and with Aging. Oxid Med Cell Longev. 2019 Nov 11;2019:3849692.
  • Iwamoto T et al. Inhibition of low-??density lipoprotein oxidation by astaxanthin. J Atheroscler Throm 2000;7:216-??222.
  • Wolf AM et al. Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress.J Nutr Biochem 2010;21:381-??389.
  • Okada Y et al. Bioavailability of astaxanthin in Haematococcus algal extract: the effects of timing of diet and smoking habits. Biosci Biotechnol Biochem 2009;73:1928-??1932.
  • Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-??aging potential. Altern Med Rev. 2011 Dec;16(4):355-??64.
  • Lu YP et al. Neuroprotective effect of astaxanthin on H(2)O(2)-??induced neurotoxicity in vitro and on focal cerebral ischemia in vivo. Brain Res. 2010 Nov
  • Sadek et al. Lycopene modulates cholinergic dysfunction, Bcl-??2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model. Can J Physiol Pharmacol. 2016 Apr;94(4):394-??401.
  • Muller L et al. Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases-?? A Critical Review. Crit Rev Food Sci Nutr. 2015 Feb 12:0.
  • Aust O et al. Lycopene oxidation product enhances gap junctional communication. Food Chem Toxicol. 2003 Oct;41(10):1399-??407.
  • Li D. et al MicroRNA-??let-??7f-??1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer. Mol Med Rep. 2016 Mar;13(3):2708-??14.
  • Szaefer H et al. Modulation of CYP1A1, CYP1A2 and CYP1B1 expression by cabbage juices and indoles in human breast cell lines. Nutr Cancer. 2012 Aug;64(6):879-??88.
  • Aggarwal BB et al. Molecular targets and anticancer potential of indole-??3-??carbinol and its derivatives. Cell Cycle. 2005 Sep;4(9):1201-??15.
  • Ganai SA. Histone deacetylase inhibitor sulforaphane: The phytochemical with vibrant activity against prostate cancer.?Biomed Pharmacother. 2016 Jul;81:250-??7.
  • Yamagishi SI et al. Protective role of sulphoraphane against vascular complications in diabetes.Pharm Biol. 2016 Feb 3:1-?? 11.
  • Lubecka-??Pietruszewska K et al. Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-??Silenced Tumour Suppressor Genes in Human Breast Cancer Cells. J Nutrigenet Nutrigenomics. 2015;8(2):91-??101.
  • Meeran SM et al. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.PLoS One. 2010 Jul 6;5(7):e11457.
  • Masci A et al. Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer’s Disease. Oxid Med Cell Longev. 2015;2015:781938.
  • Fujioka N et al. Research on cruciferous vegetables, indole-??3-??carbinol, and cancer prevention: A tribute to Lee W. Wattenberg. Mol Nutr Food Res. 2016 Jun;60(6):1228-??38.
  • Fuentes F et al. Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-??3-??Carbinol/3,3′-??Diindolylmethane: Anti-??Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy. Curr Pharmacol Rep. 2015 May;1(3):179-??196. Epub 2015 Jan 30.

Note bibliografiche in breve:

  • Galimberti D et al. La medicina dell?aging e dell?antiaging. Edra Edizioni 2016;
  • Galimberti D et al. Nutrigenomica e Epigenetica. Dalla biologia alla clinica. Edra Edizioni 2017;
  • Lau FC et al. Nutrigenomic analysis of diet-??gene interactions on functional supplements for weight management. Curr Genomics. 2008 Jun;9(4):239-??51.
  • El-??Moustafa et al. Nopal cactus (Opuntia ficus-??indica) as a source of bioactive compounds for nutrition, health and disease. Molecules. 2014 Sep 17;19(9):14879-??901.
  • Galati EM et al. Opuntia ficus indica (L.) Mill. mucilages show cytoprotective effect on gastric mucosa in rat. Phytother Res. 2007 Apr;21(4):344-??6.
  • Lopez-??Romero P et al. The effect of nopal (Opuntia ficus indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet. 2014 Nov;114(11):1811-??8.
  • Nunez-??Lopez MA et al. Functional and hypoglycemic properties of nopal cladodes (O. ficus-??indica) at different maturity stages using in vitro and in vivo tests. J Agric Food Chem. 2013 Nov 20;61(46):10981-??6.
  • Aragona M et al. Opuntia ficus-??indica (L.) as a source of bioactivity compounds for health and nutrition. Nat Prod Res. 2018 Sep;32(17):2037-??2049.
  • Abdollahi S et al. Zinc Supplementation and Body Weight: A Systematic Review and Dose-??Response Meta-??analysis of
  • Randomized Controlled Trials. Adv Nutr. 2019 Aug 22. pii: nmz084.
  • De Carvalho GB et al. Zinc’s role in the glycemic control of patients with type 2 diabetes: a systematic review. Biometals. 2017 Apr;30(2):151-??162.
  • Parafati M et al. Bergamot Polyphenols Boost Therapeutic Effects of the Diet on Non-??Alcoholic Steatohepatitis (NASH) Induced by “Junk Food”: Evidence for Anti-??Inflammatory Activity. Nutrients. 2018 Nov 1;10(11). pii: E1604.
  • Mannucci C et al. Clinical Pharmacology of Citrus bergamia: A Systematic Review. Phytother Res. 2017 Jan;31(1):27-??39.
  • Navarra M et al. Citrus bergamia essential oil: from basic research to clinical application. Front Pharmacol. 2015 Mar 2;6:36.
  • Mollace V et al. Hypoglycemic and Hypolipemic effects of a new lecithin formulation ofBergamot Polyphenolic Fraction: a double blind, randomized, placebo-??controlled study. Endocr Metab Immune Disord Drug Targets. 2018 Dec 3.
  • Giglio RV et al. The effect of bergamot on dyslipidemia. Phytomedicine. 2016 Oct 15;23(11):1175-??81.
  • Cappello AR et al. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini Rev Med Chem. 2016;16(8):619-??29.
  • Ferlazzo N et al. Anti-??Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand? Molecules. 2016 Sep
  • 23;21(10). pii: E1273.
  • Dakshinamurti K. Vitamins and their derivatives in the prevention and treatment of metabolic syndrome diseases (diabetes). Can J Physiol Pharmacol. 2015 May;93(5):355-??62.
  • Lin CC et al. Chromium, zinc and magnesium status in type 1 diabetes. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):588-??92.
  • Oi-??Kano Y et al. Oleuropein aglycone enhances UCP1 expression in brown adipose tissue in high-??fat-??diet-??induced obese rats by activating ?-??adrenergic signaling. J Nutr Biochem. 2017 Feb;40:209-??218.
  • Pevrol J et al. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Nutrients. 2017 Mar 20;9(3). pii: E306.
  • Vezza T et al. The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-??induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties. Pharmacol Res. 2019 Dec;150:104487.
  • Karkovic Markovic A et al. Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health. Molecules. 2019 May 24;24(10).
  • Parkinson L et al. The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds. Molecules. 2016 Dec 16;21(12). pii: E1734.
  • Garcia-??Moreno JC et al. Tyrosol, a simple phenol from EVOO, targets multiple pathogenic mechanisms of neurodegeneration in a C. elegans model of Parkinson’s disease. Neurobiol Aging. 2019 Oct;82:60-??68.
  • Zuniga LY et al. fect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion. J Med Food. 2017 Aug;20(8):750-??754.
  • Pothuraiu R et al. A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric. 2014 Mar 30;94(5):834-??40.
  • Tiwari P et al. Gymnema sylvestre for Diabetes: From Traditional Herb to Future’s Therapeutic. Curr Pharm Des. 2017;23(11):1667-??1676.
  • Khan F et al. Front Pharmacol. 2019 Oct 29;10:1223.
  • Paero R. In linea con le piante. Sapere&Salute, anno 4, luglio 1999, num.21, pag.28-??31.
  • Kashima H et al. Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response. Nutr Res. 2019 Aug;68:62-??69.
  • Hossain MU et al. Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs fromGymnema sylvestre against Insulin Receptor Protein. Biomed Res Int. 2016;2016:3187647.
  • Perera HK et al. Analysis of glycation induced protein cross-??linking inhibitory effects of some antidiabetic plants and spices. BMC Complement Altern Med. 2015 Jun 9;15:175.

Scopriamo il futuro

Siamo un laboratorio multidisciplinare impegnato nella ricerca mirata e la produzione di integratori alimentari innovativi